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to a tryptophan load. There are decreased levels of pyridoxal-5phosphate and gamma-aminobutyric acid (GABA) in brain tissue. The neuropathology has been studied in only a few cases. One of our patients, a 13 1/2-year-old boy affected in the neonatal period, was left in a state of mental retardation, with pale optic discs and spastic legs; the brain weight was 350 g below normal. There was a decreased amount of central white matter in the cerebral hemispheres and a depletion of neurons in the thalamic nuclei and cerebellum, with gliosis (Lott et al). Most importantly, in pyridoxine de ciency, the administration of 50 to 100 mg of vitamin B6 suppresses the seizure state, and daily doses of 40 mg permit normal development. Biopterin De ciency Some patients with increased concentrations of serum phenylalanine in the neonatal period are unresponsive to measures that lower phenylalanine. They are usually found to have a defect in biopterin metabolism. If this condition is unrecognized and not treated promptly, it leads to seizures of both myoclonic and later grand mal types combined with a poor level of responsiveness and generalized hypotonia. Swallowing dif culty is another prominent symptom. Within a few months, developmental delay becomes prominent. Unlike in PKU, phenylalanine

Checkbox Group The Checkbox Group Web item allows free characteristics to be displayed and selected as filter values in a group of check boxes. Using the Checkbox Group Web item, you can easily filter one or more connected data providers according to one or more characteristic values. You can set or remove filter values in the Web application by setting one or more indicators. The significant difference between the Radio Button Group and the Checkbox Group is that the Radio Button Group Web item allows the selection of only one

Figure 20-2 shows a mapping that s almost the same as the mapping of Fig. 20-1. The only difference is that there is an extra element in set B, and it maps to one of the existing elements

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The sign, Bittersweet Inn A Shared Home for Loved Elderly, stood along the driveway of the large, white, three-story colonial house. A single-story ell connected the main building with a huge barn, making this a typically charming New England farm complex. At one side, the corn towered over a large vegetable garden and a flower garden surrounded by bird feeders. A stately woman with gray hair walked over to greet us. I m Mrs. Taylor, one of the residents, she announced. Looking for Brenda Bachmann Yes, please. She nodded toward the house. You ll find her in the living room. Can t miss her because she s petite, pretty, blonde, and, she paused and smiled almost mischievously, she s cute as a bug s ear! A moment later, the woman so accurately described greeted us at the door. I m so pleased you could come. Let me show you around our home. By the way, call me Brenda. We like informality here. As we made the usual small talk following introductions, we noted that the attractive large living room had wide floorboards that ran the width of the room and contrasted nicely with the rich burgundy curtains. A mauve rose-floral overstuffed sofa and several cherry wingback chairs with end tables standing on a roseivory rug made an inviting setting. She led us into the formal dining room, which was furnished with a cherry table and matching chairs. The mint-green walls complemented the dark green floor with its trailing ivy motif. A four-tiered chandelier complemented the white, floor-length, hand-crocheted tablecloth; the table was set for eight with a service of Old Rose patterned china. We ve tried to restore and furnish the house as it might have been back in 1840 and decided to use cherry furniture, she

The Format toolbar lets you modify the font and font size; apply bold and italic; adjust the alignment of the selected text; and change the background color of the Web template, the text color, and the text background color. You can also use the <DIV> and <SPAN>

Boundory-Volue Problems 540 22.1 lntrodvction Bockground 541 ond Method 545 22.2 lhe Shooting 22.3 Finite-Difference Methods 552 P r o b l e m s5 5 9

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