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In the past decade the concept of evidence-based medicine (EBM) has strongly in uenced the research of PE The results of PE drug clinical trials are only reliable, interpretable and capable of being generalized to patients with the disorder studied when conducted in well-de ned and consistent populations, using a double blind placebo-controlled study design with consistent objective physiologic measures or sensitive, validated outcome assessment instruments as study endpoints [41] Optimal clinical trial design will facilitate subsequent meta-analysis of results, and is one of the goals of an evidencebased approach to medicine [29] Clinical trial design differs etween research into the methodology of diagnosis and research into treatment ef cacy.

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Ejaculatory Disorders graphically and etiologically distinct disorders and analyzed as separate PE subgroups [42] Subjects should be involved in a stable, monogamous heterosexual relationship, prepared to attempt intercourse on a regular basis, and provide written informed consent The presence of comorbid erectile dysfunction (ED) should be evaluated using a validated instrument such as the international index of erectile function (IIEF), and atients with any degree of ED should be either excluded from the study or treated as a separate subgroup Patients with hypoactive sexual desire or other sexual disorders, urogenital infection, major psychiatric disorders, a history of drug and alcohol abuse or contraindications to the study drug should be excluded from the study A very important issue is the de nition of lifelong PE and acquired PE In recent years most attention has focused on an adequate de nition of lifelong PE and much less to acquired PE For the diagnosis of lifelong PE both objective and subjective items have been proposed but none are universally accepted As such, a consensus of a de nition of lifelong PE has not been reached There is general agreement that the DSM de nition of PE is vague and multiinterpretable [12] It contains mainly qualitative descriptions and not quantitative values, which makes the current DSM-IV de nition inappropriate for scienti c research Research papers stating that PE is de ned by the DSM-IV de nition should therefore add more diagnostic information of the patients that are included in the study Outcome measures such as the intravaginal ejaculation latency time (IELT), and patient subjective assessments of control, distress (bother), and sexual satisfaction, using validated patient reported instruments [26 28], form the basis of diagnostic research.

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The spectral shape of the uorescence emission with an excitation at 340 nm provided the information about the concentration of the branched product in the olymer and the selectivity of a catalyst used for the melt polymerization21,58 61 A representative uorescence spectrum (along with an excitation line at 340 nm) from a single microreactor in the array is illustrated in Figure 53B The rst-order measurements were used for the optimization of melt-polymerization reaction conditions as described in Section 51 When measurements are done with a rst-order instrument, and there is another independent variable involved, this constitutes a second-order measurement approach This type of screening was used for the in situ monitoring of melt-polymerization reactions (see Section 54) and for the evaluation of the sensor materials Figure 5.

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4A shows a 48-element array of sensor materials positioned in a gas ow-cell for the monitoring of the materials response upon exposure to vapors of interest For the evaluation of sensor materials, absorption spectra were collected over a period of time of reaction of these sensor materials with a vapor of interest Results of these measurements are illustrated in Figure 54B Adding two more independent variable parameters to the response of a rst-order system obviously makes it a third-order measurement approach An example of such system is spectroscopic monitoring (wavelength is the variable parameter I) of the reaction progress of combinatorial materials (time is the variable parameter J) at different process temperatures (temperature is the variable parameter K) Alternatively, a second-order system can be implemented for the measurements as a function of one or more independent parameters.

An alien method invoked outside of a synchronized region is known as an open call [Lea00, 2413] Besides preventing deadlocks, open calls can greatly increase concurrency An alien method might run for an arbitrarily long period, during which time other threads would unnecessarily be denied access to the shared object if the alien method were invoked inside the synchronized region As a rule, you should do as little work as possible inside synchronized regions Obtain the lock, examine the shared data, transform the data s necessary, and drop the lock If you must perform some time-consuming activity, find a way to move the activity out of the synchronized region Invoking an alien method from within a synchronized region can cause failures more severe than deadlocks if the alien method is invoked while the invariants protected by the synchronized region are temporarily invalid (This cannot happen in the broken work queue example because the queue is in a consistent state when processItem is invoked) Such failures do not involve the creation of a new thread from within the alien method; they occur when the alien method itself calls back in to the faulty class Because locks in the Java programming language are recursive, such calls won't deadlock as they would if they were made by another thread The calling thread already holds the lock, so the thread will succeed when it tries to acquire the lock a second time, even though there is another conceptually unrelated operation in progress on the data protected by the lock The consequences of such a failure can be catastrophic; in essence, the lock has failed to do its job Recursive locks simplify the construction of multithreaded object-oriented programs, but they can turn liveness failures into safety failures The first part of this item was about concurrency problems Now we turn our attention to performance While the cost of synchronization has plummeted since the early days of the Java platform, it will never vanish entirely If a frequently used operation is synchronized unnecessarily, it can have significant impact on performance For example, consider the classes StringBuffer and BufferedInputStream These classes are thread-safe (Item 52) but are almost always used by a single thread, so the locking they do is usually unnecessary They support fine-grained methods, operating at the individual character or byte level, so not only do these classes tend to do unnecessary locking, but they tend to do a lot of it This can result in significant performance loss One paper reported a loss close to 20 percent in a realworld application [Heydon99] You are unlikely to see performance losses this dramatic caused by unnecessary synchronization, but 5 to 10 percent is within the realm of possibility Arguably this belongs to the small efficiencies that Knuth says we should forget about (Item 37) If, however, you are writing a low-level abstraction that will generally be used by a single thread or as a component in a larger synchronized object, you should consider refraining from synchronizing the class internally Whether or not you decide to synchronize a class, it is critical that you document its thread-safety properties (Item 52) It is not always clear whether a given class should perform internal synchronization In the nomenclature of Item 52, it is not always clear whether a class should be made thread-safe or thread-compatible Here are a few guidelines to help you make this choice If you're writing a class that will be used heavily in circumstances requiring synchronization and also in circumstances where synchronization is not required, a reasonable approach is to provide both synchronized (thread-safe) and unsynchronized (thread-compatible) variants.

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Examples of second-order systems are excitationemission luminescence measurement systems, GC-MS, and HPLC-diode array UV systems, among others An example of one of our third-order measurement approaches for combinatorial screening is illustrated in Figure 55 It was implemented for the determination of oxidative stability of polymers under different process conditions (temperature I and time J) multivariate data analysis tools PDF 417 Recognizer In PDF-417 2d Barcode Generation In Visual Studio NET a>Related: .

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